Two sample MR report
HP_Alveolar Macrophages against UKB-b-18436
Date: 13 January, 2026
Results from two sample MR:
| method | nsnp | b | se | pval |
|---|---|---|---|---|
| MR Egger | 12 | -0.0398012 | 0.0380117 | 0.3197132 |
| Weighted median | 12 | 0.0190579 | 0.0066265 | 0.0040274 |
| Inverse variance weighted | 12 | 0.0177555 | 0.0054042 | 0.0010179 |
| Simple mode | 12 | 0.0303927 | 0.0130340 | 0.0397429 |
| Weighted mode | 12 | 0.0246757 | 0.0114753 | 0.0546153 |
Heterogeneity tests
| method | Q | Q_df | Q_pval |
|---|---|---|---|
| MR Egger | 12.37395 | 10 | 0.2608084 |
| Inverse variance weighted | 15.26306 | 11 | 0.1707679 |
Test for directional horizontal pleiotropy
| egger_intercept | se | pval |
|---|---|---|
| 0.0468216 | 0.0306421 | 0.1575002 |
Test that the exposure is upstream of the outcome
| snp_r2.exposure | snp_r2.outcome | correct_causal_direction | steiger_pval |
|---|---|---|---|
| 0.0004095 | 0 | TRUE | 0.0557644 |
Note - R^2 values are approximate
Forest plot of single SNP MR
Comparison of results using different MR methods
Funnel plot
Leave-one-out sensitivity analysis
